zeyi guan
Learn About Me
I am currently an R&D Engineer in Medtronic Peripheral Vascular, working on new product development. Prior to that, I worked for WondfoUSA in San Deigo, CA, supporting the new product development of in vitro diagnostic devices, more specifically, compact qPCR for RNA virus detection. I graduated with a Ph.D. in Mechanical Engineering from UCLA in 2020, with a dissertation thesis towards the advanced manufacturing methods development and material characterization of Zinc matrix nanocomposite as biodegradable metals for biomedical application. My interests include advanced metal processing (metal 3D printing), medical device design and development (e.g., biodegradable implants), advanced testing method development (e.g., corrosion fatigue), modeling and simulation (e.g., CAD and Matlab).
Professional Outlook
Where I Am. Where I’m Going.
I have been participating in medical devices development for more than 8 years, including various products in multiple fields, both in academia and industry, including bioimaging, bioresorbable cardiovascular stent, bioelectronics, drug-coated balloon, drug-eluting stent, embolization device, etc.Â
I am looking forward to opportunities to broaden my vision in the field of medical devices, with creations, new ideas, interdisciplinary applications, and fundamental works. I would love to bring challenges to my life, pursuing unknowns, learning while working, and being a successful engineer and researcher.
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Experience
Work History
R&D Engineer II - Medtronic Peripheral Vascular
July 2021 -Â Present
·        Led the test method development of fatigue testing method and simulated use testing method for Drug Eluting Stent (Peripheral Resolute Onyx DES)
·        Managed the documentation release of new product development, including Product Standard List, Human Factor Engineering and Design Concept.
·        Led the Root Cause Analysis of the balloon twist for Drug Coated Balloon, performed experiments for problem investigation, applied DOE for proposed solution/corrective action
Mechanical Engineer - WondfoUSA
June 2025 - April 2026
·        Led the new product development of portable RT-qPCR instrument for COVID-19/Flu A/Flue B in phase 0 for conceptualization
·        Designed the prototype using Solidworks and utilize 3D printing/CNC machining for prototypes for functional validation
·        Collaborate with external vendors for thermoelectric and optics subassembly selection
·        Engaged in instrument functional verification and device optimization in the collaboration with assay team
Educational Experience
What I’ve Learned
Bachelor of Science, Mechanical Engineering
UCLA, Los Angeles
2011-2015
Dean's List, 2012 winter, spring, fall, 2013 winter
Top 5% of class
Ph.D, Mechanical Engineering
UCLA, Los Angeles
2015-present
Proposed research direction: Thermal fiber drawing of nanocomposite nanowire and metal matrix nanocomposite fabrication
Research Experience
My Experience in Laboratory
06/2013 – 09/2015
Undergraduate Research assitant, UCLA-Microsystem Laboratory
Worked on Light Sheet Illumination Microscopy system under supervision of Dr. Chih-Ming Ho (P.I.) and Dr. Peng Fei (Research Mentor)
Light Sheet Illumination Plus (LSIP) ​
Designed and fabricated a compact add-on device for inverted microscopy enabling light sheet illumination for 3D bioimaging
Utilized CAD (Solidworks) for design and optimization, and applied FDM 3D printing for manufacturing.
Conducted fine manual machining using lase, drill, mill, tap, and assembly
Conducted research on light sheet illumination system and super-resolution theory
Conducted research on GFP Zebrafish anesthetic operation and cell staining process with Alexa 488
Mastered inverted microscopy operation and imaging with camera control
Mastered experimental data collection and imaging processing with ImageJ and Amira.
Opto-fluidics
Worked on combining Selective plan illuminating microscopy (SPIM) with microfluidic chips for on-chip 3D bioimaging
Constructed on-bench SPIM by aligning optical elements and organized a simultaneous image feedback system for data collection and analysis
Be trained MR90 cell staining process with DAPI and Alexa488
Mastered PDMS based microfluidics chip design and fabricating using MEMS (photolithography).
PDMS-glass binding or PDMS-PDMS binding by using plasma cleaner or liquid PDMS heating method.
LabView program control of laser switches.
09/2015 - 09/2020
Graduate Research assistant, UCLA Scifacturing Lab
Worked on metal matrix nanocomposite (MMNC) manufacturing and thermal fiber drawing under the supervision of Dr. Xiaochun Li
Metal nanowire thermal fiber drawing
Using thermal fiber drawing to manufacture metal nanowire within glass cladding for mechanical, electrical, and biomedical applications
Conducted thermal drawing using high temperature thermal drawig tower
Conducted academic research on manufacturing, fluid mechanics, and thermal transfer
Mastered mechanical design using CAD and system control using Labview
Conducted MEMS techniques in clean room, including wet etching, deposition, and oxide etching
High strength metal matrix nanocomposite manufacturing
​Worked on metal matrix nanocomposite fabrication by incorporation in high temperature furnace
Conducted research on metal manufacturing using casting, forging, rolling, and etc.
Mastered nanocomposite incorporation on metal matrix, such as copper, silver, and zinc.
Well trained on material characterization using SEM and TEM
Bio-compatible Zinc nanocomposite artery stent fabrication
Performed fabrication of functional devices using Zn nanocomposite for biomedical fields
Conducted research on artery stent fabrication and charaterization
Conducted nanocomposite tube fabrication using vacuum suction method
Well trained on bio-compatibility characterization
2016-2018
Teaching Assitant
Worked at UCLA mechanical engineering department as TA
Course MAE 183A "Manufacturing"
Course MAE 297A "Rapid prototyping"
Course MAE 154B "Design of Aerospace Structures"​
Patents
WO2020028643A1
Biodegradable zinc-based materials including dispersed nanostructures for biomedical applications
UC-2014-9AH-1-LA
Plane Illumination Plugin Device to Enable Light Sheet Fluorescence Imaging of Multi-Cellular Organisms on an Inverted Wide-Field Microscope. (UCLA provisional Patent)
Certificates
GD&T Fundamentals 2009 Online Courses
SAE International
Issued Feb. 2022
Machine Learning
Coursera
Issued Mar. 2021
Proficiencies
What I Mastered
Professional skills
Computer Aided Design (Solidworks, AutoCAD)
Coding (Matlab, C++, LabView)
Imaging processing (Amira, ImageJ)
MEMS (AFM, AOE etcher, ALD, Sputterer, HF vapor etcher)
Microscopy (SEM, EDX)
Mechanical Testing (Instron, Zwick, Tensile testing, Fatigue testing, Bending testing)
Other skills
Microsoft Office Suite (Work, Excel, Powerpoint)
Publications and Conferences
Microsystem Lab
Guan, Zeyi, et al. "Compact plane illumination plugin device to enable light sheet fluorescence imaging of multi-cellular organisms on an inverted wide-field microscope." Biomedical optics express 7.1 (2016): 194-208.
Jiang, Hao, et al. "Droplet-based light-sheet fluorescence microscopy for high-throughput sample preparation, 3-D imaging and quantitative analysis on a chip." Lab on a Chip17.13 (2017): 2193-2197.
Scifactruing Lab
Guan, Zeyi, et al. "Zn–Mg–WC Nanocomposites for Bioresorbable Cardiovascular Stents: Microstructure, Mechanical Properties, Fatigue, Shelf Life, and Corrosion." ACS Biomaterials Science & Engineering (2021).
Guan, Z., Hwang, Injoo, et al. "Nanoparticles suppress fluid instabilities in the thermal drawing of ultralong nanowires." Nature communications 11.1 (2020): 1-7..
Guan, Zeyi, et al. "Scalable Manufacturing of AgCu40 (wt%)–WC Nanocomposite Microwires." Journal of Micro and Nano-Manufacturing 6.3 (2018): 031008.
Guan, Zeyi, Injoo Hwang, and Xiaochun Li. "Highly Concentrated WC Reinforced Ag Matrix Nanocomposite Manufactured by Molten Salt Assisted Stir Casting." Procedia Manufacturing 26 (2018): 146-151.
Guan, Zeyi, et al. "Manufacturing and Characterization of Zn-WC as Potential Biodegradable Material." Procedia Manufacturing 34 (2019): 247-251.
Guan, Zeyi, et al. "Novel Zinc/Tungsten Carbide Nanocomposite as Bioabsorbable Implant." Materials Letters (2019): 127282.
Guan, Zeyi, et al. "Highly Ductile Zn-2Fe-WC Nanocomposite as Biodegradable Material." Metallurgical and Materials Transactions A (2020): 1-8.
Guan, Zeyi, et al. "Fabrication and Characterization of In Situ Zn-TiB2 Nanocomposite." Procedia Manufacturing 48 (2020): 332-337.
Yao, Gongcheng, et al. "A novel process for manufacturing copper with size-controlled in-situ tungsten nanoparticles by casting." Journal of Materials Processing Technology 296 (2021): 117187.
Pan, Shuaihang, et al. "Mo-enhanced chemical stability of TiC nanoparticles in molten Al." Journal of Alloys and Compounds 856 (2021): 158169.
Pan, Shuaihang, Zeyi Guan, and Xiaochun Li. "Unusual thermal performance in Cu-60Ag by WC nanoparticles." Materials Science and Engineering: B 265 (2021): 115010.
Li, Jasmine, et al. "Fabrication and characterization of bioresorbable zinc/WC nanocomposite springs for short bowel syndrome treatment." Materials Letters 280 (2020): 128577.
Pan, Shuaihang, et al. "Kinetics and dynamics of surface thermal oxidation in Al-ZrB2 nanocomposites." Corrosion Science 176 (2020): 108890.
Cao, Chezheng, et al. "Bulk ultrafine grained/nanocrystalline metals via slow cooling." Science advances 5.8 (2019): eaaw2398.
Pan, Shuaihang, et al. "Enhanced thermal stability in Cu-40 wt% Zn/WC nanocomposite." Materials & Design (2019): 107964.
Pan, Shuaihang, et al. "Facile fabrication and enhanced properties of Cu-40 wt% Zn/WC nanocomposite." Journal of Alloys and Compounds 784 (2019): 237-243.
Pan, Shuaihang, et al. "Study on electrical behaviour of copper and its alloys containing dispersed nanoparticles." Current Applied Physics 19.4 (2019): 452-457.
Hwang, Injoo, Zeyi Guan, and Xiaochun Li. "Scalable Manufacturing of Zinc-Tungsten Carbide Nanocomposites." Procedia Manufacturing 26 (2018): 140-145.
Hwang, Injoo, Zeyi Guan, and Xiaochun Li. "Fabrication of Zinc–Tungsten Carbide Nanocomposite Using Cold Compaction Followed by Melting." Journal of Manufacturing Science and Engineering 140.8 (2018): 084503.
Jiang, Hao, et al. "Droplet-based light-sheet fluorescence microscopy for high-throughput sample preparation, 3-D imaging and quantitative analysis on a chip." Lab on a Chip17.13 (2017): 2193-2197.
Zhao, Jingzhou, et al. "Scalable Manufacturing of Metal Nanoparticles by Thermal Fiber Drawing." Journal of Micro and Nano-Manufacturing 4.4 (2016): 041002.
Yao, Gongcheng, et al. "Casting In-Situ Cu/CrBx Composites via Aluminum-Assisted Reduction." Procedia Manufacturing 48 (2020): 320-324.
Conference
Advances in Microfluidics and Nanofluidics 2018, Beijing China
Attendee
NAMRC 46, 2017, Los Angeles, CA
Volunteer
NAMRC 47, 2018, College Station, TX
Presenter for "Highly Concentrated WC reinforced Ag Matrix Nanocomposite Manufactured by Molten Salt Assisted Stir Casting", author Zeyi Guan
Presenter for "Scalable manufacturing of Zinc-Tungsten Carbide Nanocomposite", author Injoo Hwang
Presenter for "Fabrication of High Strength Al Nanocomposites with populous TiB2 Nanoparticles", author Abdolreza Javadi
Projects
Projects in college and graduate school, specifically in project-oriented course and academic researches
Golfball delivering robot
UCLA MAE 162D/E capstone course project
We have designed and manufactured a robot that can autonomously find an entrance, navigate a twisting ramp, drop off a golf ball a certain distance away from the end of the
ramp, and return to the center.
The main challenges include avoiding the ramp walls and accurately delivering the golf ball.
"Well done is better than well said"
Benjamin Franklin
Get in Touch
420 Westwood Plaza
Los Angeles, Los Angeles County 90095
USA
310-721-5821
