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zeyi guan

Learn About Me

I am currently an R&D Engineer in Medtronic Peripheral Vascular, working on new product development. Prior to that, I worked for WondfoUSA in San Deigo, CA, supporting the new product development of in vitro diagnostic devices, more specifically, compact qPCR for RNA virus detection. I graduated with a Ph.D. in Mechanical Engineering from UCLA in 2020, with a dissertation thesis towards the advanced manufacturing methods development and material characterization of Zinc matrix nanocomposite as biodegradable metals for biomedical application. My interests include advanced metal processing (metal 3D printing), medical device design and development (e.g., biodegradable implants), advanced testing method development (e.g., corrosion fatigue), modeling and simulation (e.g., CAD and Matlab).

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Home: Welcome

Professional Outlook

Where I Am. Where I’m Going.

I have been participating in medical devices development for more than 8 years, including various products in multiple fields, both in academia and industry, including bioimaging, bioresorbable cardiovascular stent, bioelectronics, drug-coated balloon, drug-eluting stent, embolization device, etc. 
I am looking forward to opportunities to broaden my vision in the field of medical devices, with creations, new ideas, interdisciplinary applications, and fundamental works. I would love to bring challenges to my life, pursuing unknowns, learning while working, and being a successful engineer and researcher.

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Home: Personal Statement
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Experience

Work History

R&D Engineer II - Medtronic Peripheral Vascular

July 2021 - Present

·         Led the test method development of fatigue testing method and simulated use testing method for Drug Eluting Stent (Peripheral Resolute Onyx DES)
·         Managed the documentation release of new product development, including Product Standard List, Human Factor Engineering and Design Concept.
·         Led the Root Cause Analysis of the balloon twist for Drug Coated Balloon, performed experiments for problem investigation, applied DOE for proposed solution/corrective action

Mechanical Engineer - WondfoUSA

June 2025 - April 2026

·         Led the new product development of portable RT-qPCR instrument for COVID-19/Flu A/Flue B in phase 0 for conceptualization
·         Designed the prototype using Solidworks and utilize 3D printing/CNC machining for prototypes for functional validation
·         Collaborate with external vendors for thermoelectric and optics subassembly selection
·         Engaged in instrument functional verification and device optimization in the collaboration with assay team

Home: Experience

Educational Experience

What I’ve Learned

Bachelor of Science, Mechanical Engineering
UCLA, Los Angeles

2011-2015

  • Dean's List, 2012 winter, spring, fall, 2013 winter

  • Top 5% of class

Ph.D, Mechanical Engineering
UCLA, Los Angeles

2015-present

  • Proposed research direction: Thermal fiber drawing of nanocomposite nanowire and metal matrix nanocomposite fabrication

Home: Education
Male Scientist

Research Experience

My Experience in Laboratory

06/2013 – 09/2015

Undergraduate Research assitant, UCLA-Microsystem Laboratory

Worked on Light Sheet Illumination Microscopy system under supervision of Dr. Chih-Ming Ho (P.I.) and Dr. Peng Fei (Research Mentor)

Light Sheet Illumination Plus (LSIP)                                 â€‹

Designed and fabricated a compact add-on device for inverted microscopy enabling light sheet illumination for 3D bioimaging

  • Utilized CAD (Solidworks) for design and optimization, and applied FDM 3D printing for manufacturing.

  • Conducted fine manual machining using lase, drill, mill, tap, and assembly

  • Conducted research on light sheet illumination system and super-resolution theory

  • Conducted research on GFP Zebrafish anesthetic operation and cell staining process with Alexa 488

  • Mastered inverted microscopy operation and imaging with camera control

  • Mastered experimental data collection and imaging processing with ImageJ and Amira.

Opto-fluidics

Worked on combining Selective plan illuminating microscopy (SPIM) with microfluidic chips for on-chip 3D bioimaging

  • Constructed on-bench SPIM by aligning optical elements and organized a simultaneous image feedback system for data collection and analysis

  • Be trained MR90 cell staining process with DAPI and Alexa488

  • Mastered PDMS based microfluidics chip design and fabricating using MEMS (photolithography).

  • PDMS-glass binding or PDMS-PDMS binding by using plasma cleaner or liquid PDMS heating method. 

  • LabView program control of laser switches.

09/2015 - 09/2020

Graduate Research assistant, UCLA Scifacturing Lab

Worked on metal matrix nanocomposite (MMNC) manufacturing and thermal fiber drawing under the supervision of Dr. Xiaochun Li

Metal nanowire thermal fiber drawing

Using thermal fiber drawing to manufacture metal nanowire within glass cladding for mechanical, electrical, and biomedical applications 

  • Conducted thermal drawing using high temperature thermal drawig tower

  • Conducted academic research on manufacturing, fluid mechanics, and thermal transfer

  • Mastered mechanical design using CAD and system control using Labview

  • Conducted MEMS techniques in clean room, including wet etching, deposition, and oxide etching

High strength metal matrix nanocomposite manufacturing

​Worked on metal matrix nanocomposite fabrication by incorporation in high temperature furnace

  • Conducted research on metal manufacturing using casting, forging, rolling, and etc.

  • Mastered nanocomposite incorporation on metal matrix, such as copper, silver, and zinc.

  • Well trained on material characterization using SEM and TEM

Bio-compatible Zinc nanocomposite artery stent fabrication

Performed fabrication of functional devices using Zn nanocomposite for biomedical fields

  • Conducted research on artery stent fabrication and charaterization

  • Conducted nanocomposite tube fabrication using vacuum suction method

  • Well trained on bio-compatibility characterization

2016-2018

Teaching Assitant

Worked at UCLA mechanical engineering department as TA

  • Course MAE 183A "Manufacturing"

  • Course MAE 297A "Rapid prototyping"

  • Course MAE 154B "Design of Aerospace Structures"​

Home: Experience

Patents

WO2020028643A1

Biodegradable zinc-based materials including dispersed nanostructures for biomedical applications

UC-2014-9AH-1-LA

Plane Illumination Plugin Device to Enable Light Sheet Fluorescence Imaging of Multi-Cellular Organisms on an Inverted Wide-Field Microscope. (UCLA provisional Patent)

Home: Experience

Certificates

GD&T Fundamentals 2009 Online Courses

SAE International

Issued Feb. 2022

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Machine Learning

Coursera

Issued Mar. 2021

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Home: Skills

Proficiencies

What I Mastered

Professional skills

  • Computer Aided Design (Solidworks, AutoCAD)

  • Coding (Matlab, C++, LabView)

  • Imaging processing (Amira, ImageJ)

  • MEMS (AFM, AOE etcher, ALD, Sputterer, HF vapor etcher)

  • Microscopy (SEM, EDX)

  • Mechanical Testing (Instron, Zwick, Tensile testing, Fatigue testing, Bending testing)

Other skills

  • Microsoft Office Suite (Work, Excel, Powerpoint)

Home: Skills
Open Book

Publications and Conferences

Home: Publications

Microsystem Lab

  • Guan, Zeyi, et al. "Compact plane illumination plugin device to enable light sheet fluorescence imaging of multi-cellular organisms on an inverted wide-field microscope." Biomedical optics express 7.1 (2016): 194-208.

  • Jiang, Hao, et al. "Droplet-based light-sheet fluorescence microscopy for high-throughput sample preparation, 3-D imaging and quantitative analysis on a chip." Lab on a Chip17.13 (2017): 2193-2197.

Scifactruing Lab

  • Guan, Zeyi, et al. "Zn–Mg–WC Nanocomposites for Bioresorbable Cardiovascular Stents: Microstructure, Mechanical Properties, Fatigue, Shelf Life, and Corrosion." ACS Biomaterials Science & Engineering (2021).

  • Guan, Z., Hwang, Injoo, et al. "Nanoparticles suppress fluid instabilities in the thermal drawing of ultralong nanowires." Nature communications 11.1 (2020): 1-7..

  • Guan, Zeyi, et al. "Scalable Manufacturing of AgCu40 (wt%)–WC Nanocomposite Microwires." Journal of Micro and Nano-Manufacturing 6.3 (2018): 031008.

  • Guan, Zeyi, Injoo Hwang, and Xiaochun Li. "Highly Concentrated WC Reinforced Ag Matrix Nanocomposite Manufactured by Molten Salt Assisted Stir Casting." Procedia Manufacturing 26 (2018): 146-151.

  • Guan, Zeyi, et al. "Manufacturing and Characterization of Zn-WC as Potential Biodegradable Material." Procedia Manufacturing 34 (2019): 247-251.

  • Guan, Zeyi, et al. "Novel Zinc/Tungsten Carbide Nanocomposite as Bioabsorbable Implant." Materials Letters (2019): 127282.

  • Guan, Zeyi, et al. "Highly Ductile Zn-2Fe-WC Nanocomposite as Biodegradable Material." Metallurgical and Materials Transactions A (2020): 1-8.

  • Guan, Zeyi, et al. "Fabrication and Characterization of In Situ Zn-TiB2 Nanocomposite." Procedia Manufacturing 48 (2020): 332-337.

  • Yao, Gongcheng, et al. "A novel process for manufacturing copper with size-controlled in-situ tungsten nanoparticles by casting." Journal of Materials Processing Technology 296 (2021): 117187.

  • Pan, Shuaihang, et al. "Mo-enhanced chemical stability of TiC nanoparticles in molten Al." Journal of Alloys and Compounds 856 (2021): 158169.

  • Pan, Shuaihang, Zeyi Guan, and Xiaochun Li. "Unusual thermal performance in Cu-60Ag by WC nanoparticles." Materials Science and Engineering: B 265 (2021): 115010.

  • Li, Jasmine, et al. "Fabrication and characterization of bioresorbable zinc/WC nanocomposite springs for short bowel syndrome treatment." Materials Letters 280 (2020): 128577.

  • Pan, Shuaihang, et al. "Kinetics and dynamics of surface thermal oxidation in Al-ZrB2 nanocomposites." Corrosion Science 176 (2020): 108890.

  • Cao, Chezheng, et al. "Bulk ultrafine grained/nanocrystalline metals via slow cooling." Science advances 5.8 (2019): eaaw2398.

  • Pan, Shuaihang, et al. "Enhanced thermal stability in Cu-40 wt% Zn/WC nanocomposite." Materials & Design (2019): 107964.

  • Pan, Shuaihang, et al. "Facile fabrication and enhanced properties of Cu-40 wt% Zn/WC nanocomposite." Journal of Alloys and Compounds 784 (2019): 237-243.

  • Pan, Shuaihang, et al. "Study on electrical behaviour of copper and its alloys containing dispersed nanoparticles." Current Applied Physics 19.4 (2019): 452-457.

  • Hwang, Injoo, Zeyi Guan, and Xiaochun Li. "Scalable Manufacturing of Zinc-Tungsten Carbide Nanocomposites." Procedia Manufacturing 26 (2018): 140-145.

  • Hwang, Injoo, Zeyi Guan, and Xiaochun Li. "Fabrication of Zinc–Tungsten Carbide Nanocomposite Using Cold Compaction Followed by Melting." Journal of Manufacturing Science and Engineering 140.8 (2018): 084503.

  • Jiang, Hao, et al. "Droplet-based light-sheet fluorescence microscopy for high-throughput sample preparation, 3-D imaging and quantitative analysis on a chip." Lab on a Chip17.13 (2017): 2193-2197.

  • Zhao, Jingzhou, et al. "Scalable Manufacturing of Metal Nanoparticles by Thermal Fiber Drawing." Journal of Micro and Nano-Manufacturing 4.4 (2016): 041002.

  • Yao, Gongcheng, et al. "Casting In-Situ Cu/CrBx Composites via Aluminum-Assisted Reduction." Procedia Manufacturing 48 (2020): 320-324.

Conference

  • Advances in Microfluidics and Nanofluidics 2018, Beijing China

    • Attendee

  • NAMRC 46, 2017, Los Angeles, CA

    • Volunteer

  • NAMRC 47, 2018, College Station, TX

    • Presenter for "Highly Concentrated WC reinforced Ag Matrix Nanocomposite Manufactured by Molten Salt Assisted Stir Casting", author Zeyi Guan

    • Presenter for "Scalable manufacturing of Zinc-Tungsten Carbide Nanocomposite", author Injoo Hwang

    • Presenter for "Fabrication of High Strength Al Nanocomposites with populous TiB2 Nanoparticles", author Abdolreza Javadi

Projects

Projects in college and graduate school, specifically in project-oriented course and academic researches

Golfball delivering robot

UCLA MAE 162D/E capstone course project

We have designed and manufactured a robot that can autonomously find an entrance, navigate a twisting ramp, drop off a golf ball a certain distance away from the end of the
ramp, and return to the center.
The main challenges include avoiding the ramp walls and accurately delivering the golf ball.

Home: Projects

"Well done is better than well said"

Benjamin Franklin

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Get in Touch

Thanks for submitting!

420 Westwood Plaza
Los Angeles, Los Angeles County 90095
USA

310-721-5821

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